Abstract The unique ability of the osteoclasts to resorb the calcified bone matrix is dependent on secretion of hydrochloric acid. This process is mediated by a vacuolar H+ ATPase (V-ATPase) and a chloride-proton antiporter. The structural subunit of the V-ATPase, a3, is highly specific for osteoclasts, and mutations in a3 lead to infantile malignant osteopetrosis, […]
Disruption of the V-ATPase functionality as a way to uncouple bone formation and resorption – a novel target for treatment of osteoporosis.
March 1, 2012
Curr Protein Pept Sci