Abstract OBJECTIVES Here, we tested the hypothesis that human M-CSF (hM-CSF) overexpressed in cord blood (CB) CD34 cells would induce differentiation and survival of monocytes and osteoclasts in vitro and in vivo. METHODS Human M-CSF was overexpressed in cord blood CD34 cells using a lentiviral vector. RESULTS We show that LV-hM-CSF-transduced CB CD34 cells expand […]
Forced expression of human macrophage colony-stimulating factor in CD34(+) cells promotes monocyte differentiation in vitro and in vivo but blunts osteoclastogenesis in vitro.
May 1, 2017
Eur J Haematol