Abstract Estrogen deficiency arising with the menopause promotes marked acceleration of bone resorption, which can be restored by hormone replacement therapy. The inhibitory effects of estrogen seem to involve indirect cytokine- mediated effects via supporting bone marrow cells, but direct estrogen-receptor mediated effects on the bone-resorbing osteoclasts have also been proposed. Little information is available […]
Estrogen directly attenuates human osteoclastogenesis, but has no effect on resorption by mature osteoclasts.
August 1, 2006
DNA Cell Biol