Abstract Cardiac fibrosis contributes to the development of heart failure in pulmonary hypertension. We aimed to assess the development of fibrosis and the effects of treatment with the anti-fibrotic agent pirfenidone in pressure overload induced right ventricular (RV) failure. Wistar rat weanlings were randomized to pulmonary trunk banding (PTB) or sham surgery. One week after […]
Pressure overload induced right ventricular remodeling is not attenuated by the anti-fibrotic agent pirfenidone.
June 1, 2019
Pulm Circ