Abstract BACKGROUND Endotrophin, a collagen type VI-derived peptide, mediates metabolic dysregulation, inflammation, and fibrosis in animal models, but has not been studied in human heart failure (HF). METHODS We examined the association between circulating endotrophin and outcomes in participants suffering from HF with preserved ejection fraction (HFpEF) enrolled in the TOPCAT trial (n=205). Associations were […]
Endotrophin, a Collagen VI Formation-Derived Peptide, in Heart Failure.
October 1, 2022
NEJM Evid