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Author Correction: c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis.
January 1, 2021
Nat Metab
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c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis.
November 1, 2020
Nat Metab
Abstract Fibrosis is a common pathological feature of chronic disease. Deletion of the NF-κB subunit c-Rel limits fibrosis in multiple organs, although the mechanistic nature of this protection is unresolved. Using cell-specific gene-targeting manipulations in mice undergoing liver damage, we elucidate a critical role for c-Rel in controlling metabolic changes required for inflammatory and fibrogenic […]
Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis.
June 1, 2020
Nat Metab
Abstract Non-alcoholic steatohepatitis (NASH) is characterized by lipotoxicity, inflammation and fibrosis, ultimately leading to end-stage liver disease. The molecular mechanisms promoting NASH are poorly understood, and treatment options are limited. Here, we demonstrate that hepatic expression of bone morphogenetic protein 8B (BMP8B), a member of the transforming growth factor beta (TGFβ)-BMP superfamily, increases proportionally to […]