Abstract The best established proteolytic event of osteoclasts is bone matrix solubilization by the cysteine proteinase cathepsin K. Here, however, we draw the attention on osteoclastic activities depending on matrix metalloproteinases (MMPs). We discuss the observations supporting that MMPs contribute significantly to bone matrix solubilization in specific areas of the skeleton and in some developmental […]
Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities.
August 15, 2003
Microsc Res Tech