Abstract Extracellular matrix remodelling is a prerequisite for plaque rupture in atherosclerotic lesion. Versican, an extracellular matrix proteoglycan present in normal and atherosclerotic arteries is a substrate for matrix metalloproteinases (MMPs) present in macrophage rich areas. The aim of the current study was to develop an immunoassay to detect a specific MMP-12 derived versican degradation […]
A MMP derived versican neo-epitope is elevated in plasma from patients with atherosclerotic heart disease.
January 1, 2013
Int J Clin Exp Med