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Serum Biomarkers of Synovial Tissue Turnover Predict Radiological Progression in Very Early RA
June 12, 2024
Serum biochemical markers of synovial tissue turnover, but not cartilage markers, predict radiological progression in very early rheumatoid arthritis
Introduction
In early rheumatoid arthritis (RA), radiographic assessments are insensitive to identify patients at high risk of progression, because the extension of joint damage, especially cartilage degradation, is rather
limited. Biochemical markers reflecting dynamic processes of tissue remodeling may be more sensitive to predict progression in early RA. To investigate whether soluble markers of matrix-metalloprotease
(MMP) driven type I (C1M) and type II (C2M) collagen degradation as:
- Indicators of synovial and cartilage tissues remodelling respectively
- Predict progression of joint damage in a prospective longitudinal
cohort of patients with early RA.
Poster
Conclusion
Increased baseline serum C1M is consistently associated with a higher risk of radiographic progression in patients with early RA. Synovial tissue remodeling may be a prominent determinant of progression in the early phase of the disease whereas cartilage turnover is likely to play a minor role at this stage.
