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PRO-C4 Is Related to Cardiometabolic Risk Factors, Steatosis, and Liver Stiffness
May 7, 2025
PRO-C4, a biomarker of perisinusoidal fibrosis, is related to cardiometabolic risk factors, steatosis, and liver stiffness
Introduction
A histological characteristic of early liver damage is the formation of perisinusoidal fibrosis with thickening of the hepatocyte basement membrane. Type IV collagen is a key component of the basement membrane of the extracellular matrix and can be assessed serologically by the biomarker PRO-C4. Thus, PRO-C4 could potentially reflect early features of liver damage in patients with early-stage SLD.
In this study we aimed to explore whether basement membrane remodeling assessed systemically was related to risk factors of chronic liver disease including Met S, liver steatosis assessed by CAP and liver
stiffness by Fibroscan.
Poster
Conclusion
Elevated PRO-C4 is associated with presence of cardiometabolic risk factors and LSM>8kpa. PRO-C4 potentially reflects perisinusoidal fibrosis from early liver damage and repair due to its relation to increasing degree of steatosis. Furthermore, PRO-C4 was also related to elevated liver stiffness in a population at risk of SLD.
