Are you interested in exploring collaboration possibilities?
Enter your information in the form and a representative will contact you shortly.
NordicPRO-C3™ and Liver Stiffness Correlate with Collagen Distribution in MASLD and ALD
May 7, 2025
Fibroblast Activity (PRO-C3) and Liver Stiffness Correlate with spatial distribution of Collagens in MASLD and ALD: Insights from Digital Pathology
Introduction
In patients with metabolic dysfunction associated steatotic liver disease (MASLD) and alcohol-related liver disease (ALD) Kleiner fibrosis stage provides limited information on the spatial distribution of collagen in the liver. Digital pathology provides a more advanced assessment of collagen localization; however, there is limited knowledge linking non-invasive tests to the spatial distribution of collagen.
In this study we aimed to explore the ability of digital pathology by second harmonic generation to evaluate fibrosis in ALD and MASDL as well as investigate the correlation between the spatial distribution of collagens and fibroblast activity (nordicPRO-C3™).
Poster
Conclusion
Correlations between spatial distribution of collagens and systemically assessed active fibrogenesis and liver stiffness in both MASLD and ALD. While similarities and differences were observed. The correlations were potentially influenced by etiology however also sample size. In conclusion, these findings underscore the connection between biopsy-based digital pathology assessments and non-invasive tests
for liver fibrosis.
