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COMP-M: A Potential Serological Biomarker of Osteoarthritis
April 18, 2024
Introduction
Cartilage oligomeric matrix protein (COMP) is an extracellular matrix (ECM) glycoprotein, consisting of five identical chains. It plays a crucial role in maintaining ECM integrity, facilitating collagen fibrils formation, and regulating cell phenotypes and functions. It is primarily found in human skeleton system, also present in adipose tissue, heart etc. Osteoarthritis (OA) involves increased activity of matrix-degrading enzymes, leading to the fragmentation of ECM.
In this study, we developed a high-sensitive chemiluminescence immunoassay for quantifying a neoepitope of COMP (DACGMQQS77↓) and explored its application as a biomarker of OA.
Poster
Conclusion
The data generated interest in the use of COMP-M as a tissue degradation biomarker of osteoarthritis.
