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Collagen Type I Degradation Biomarkers Are Associated with Risk of Mortality After STEMI
June 12, 2025
Collagen type I degradation biomarkers are associated with risk of mortality after ST-elevated
myocardial infarction.
Introduction
Following ST-elevation myocardial infarction (STEMI), there is acute degradation of type I collagen (COL1), the primary structural protein of the myocardium. This process reflects extensive extracellular matrix remodeling, which may contribute to cardiac tissue destabilization and elevate the risk of subsequent adverse events. To better understand this pathological remodeling, we aimed to quantify COL1 using specific plasma biomarkers, including a novel signaling fragment of COL1 (C1SIG) and a more established COL1 degradation marker (C1M). Additionally, we investigated the prognostic value of these biomarkers for predicting all-cause mortality following a STEMI event.
Poster
Conclusion
C1M and C1SIG are independently prognostic for mortality in STEMI patients after 1 year, in a multivariate
model based on the Framingham Score. Assessing acute extracellular matrix processing in STEMI patients
using COL1 biomarkers could be beneficial for predicting mortality and identifying a patient subset at
increased risk of long-term outcome.
