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Biomarkers of Immune Cell Activity can Identify Patients with Confirmed Crohn’s Disease
March 13, 2026
Biomarkers of neutrophil and macrophage activity discriminate non-IBD from CD and associate with endoscopic disease activity
Introduction
Crohn’s disease (CD) is a chronic inflammatory bowel diseases (IBD) characterized by immune cell infiltration and increased proteolytic activity, driving pathological changes in the structure and function of the intestines. Ileocolonoscopy (IC) is the gold standard for diagnosing and monitoring patients with CD but the invasive nature of IC renders it as least acceptable from a patient perspective. Pan-enteric endoscopy (PCE) is an attractive and less invasive method.
This study aimed to investigate whether biomarkers of immune cell activity could identify patients with suspected CD, and if they associated with endoscopic disease activity at IC and PCE.
Poster
Conclusion
CPa9-HNE [neutrophil activity] and VICM [macrophage activity] could identify patients with confirmed CD and were associated with endoscopic disease activity. Both biomarkers provided stronger discriminative performance when assessing disease activity by utilizing PCE. Biomarkers of neutrophil and macrophage activity may therefore provide additonal information to endoscopic assessment in the diagnosis and monitoring of CD.
