SPARC-M
A matrix metalloproteinase-generated fragment of SPARC, reflecting extracellular matrix remodeling and tissue remodeling activity.
Key features and values
- Serum-based assay detecting MMP-cleaved fragments of SPARC, indicative of extracellular matrix remodeling.
- Reflects tissue remodeling activity, providing insights into pathological processes involving the extracellular matrix.
- Validated for use in human blood samples, ensuring reliable and reproducible measurements.
- Non-invasive tool for assessing tissue remodeling, suitable for routine blood sampling.
- Elevated SPARC-M levels correlate with increased extracellular matrix remodeling in conditions such as multiple sclerosis.
- Useful for monitoring therapeutic response, with changes in SPARC-M levels reflecting the efficacy of treatments targeting tissue remodeling.
- Facilitates research and development of targeted therapies by providing insights into extracellular matrix remodeling mechanisms.
Description
The SPARC-M biomarker assay is designed to quantify matrix metalloproteinase (MMP)-cleaved fragments of SPARC (secreted protein acidic and rich in cysteine) in serum, serving as a specific indicator of extracellular matrix (ECM) remodeling. SPARC is a matricellular protein involved in tissue remodeling, and its cleavage by MMPs releases fragments into the bloodstream. By measuring these fragments, the assay provides a direct assessment of pathological ECM remodeling.
This assay has been validated for use in human blood samples, demonstrating its reliability and reproducibility in various clinical and research settings. Elevated serum SPARC-M levels have been associated with increased ECM remodeling in conditions such as multiple sclerosis. The non-invasive nature of the test makes it suitable for routine monitoring of tissue remodeling and the effectiveness of therapies aimed at modulating ECM dynamics.
In addition to its clinical applications, the SPARC-M assay serves as a valuable tool in research, facilitating the study of ECM remodeling mechanisms and the development of targeted treatments aimed at modulating tissue remodeling processes.
Nordic Bioscience’s assays and services are research use only products and services and do not qualify for medical or diagnostic purposes.
