PRO-C7
A fragment of the C-terminal domain of type VII collagen, the only anchoring fibril, enabling non-invasive monitoring of dermal-epidermal junction integrity and extracellular matrix formation in skin and intestinal tissue remodeling.
Key features and values
- Quantifies C-terminal fragments of type VII collagen, reflecting anchoring fibril formation.
- Provides a non-invasive measure of dermal-epidermal junction integrity.
- Supports monitoring of tissue remodeling in dermatological and gastrointestinal conditions.
- Applicable in research on diseases characterized by altered extracellular matrix turnover, such as atopic dermatitis and systemic sclerosis.
- Facilitates evaluation of interventions aimed at modulating extracellular matrix formation.
- Complements other biomarkers for a comprehensive assessment of tissue remodeling dynamics.
- Utilized in studies investigating type VII collagen turnover in systemic sclerosis and atopic dermatitis.
Description
The PRO-C7 biomarker assay measures specific fragments of the C-terminal domain of type VII collagen, serving as an indicator of anchoring fibril formation and dermal-epidermal junction integrity. This non-invasive assay provides insights into extracellular matrix formation processes associated with skin and intestinal tissue remodeling. By quantifying type VII collagen formation products, the PRO-C7 assay aids in monitoring disease progression, evaluating treatment efficacy, and understanding the underlying mechanisms of tissue remodeling. It serves as a valuable tool in research settings for assessing the dynamics of extracellular matrix turnover in dermatological and gastrointestinal conditions.
Nordic Bioscience’s assays and services are research use only products and services and do not qualify for medical or diagnostic purposes.
