Endotrophin (nordicEndotrophin™)

• Measures the intact 77-amino-acid Endotrophin hormone, a collagen-derived signaling molecule.
• Reflects fibro-inflammatory activity and pathological tissue remodeling in diverse chronic diseases.
• Enables non-invasive risk stratification and prognostic assessment in fibrosis, cancer, and metabolic disorders.
• Supports pharmacodynamic monitoring and treatment evaluation in clinical and translational studies.
• Facilitates precision-medicine approaches by linking Endotrophin levels to patient outcomes and mortality risk.
• Compatible with fully automated, high-accuracy, high-throughput analytical platforms for scalable application.

The Endotrophin (nordicEndotrophin) biomarker assay quantifies the intact 77-amino-acid signaling hormone released from type VI collagen, providing a non-invasive and specific measure of fibro-inflammatory activity and tissue remodeling. Endotrophin plays a direct role in fibroblast activation, wound healing, and the progression of fibrotic and inflammatory diseases across multiple organs, including the heart, liver, and kidney. Elevated circulating Endotrophin is strongly associated with increased risk of mortality and adverse outcomes in chronic conditions such as obesity, cardiovascular disease, renal disease, and cancer. This assay enables researchers and clinicians to link fibro-inflammatory progression and wound healing responses to patient risk, supporting precise risk stratification, pharmacodynamic monitoring, and therapeutic decision-making in anti-fibrotic and oncology studies. The high-precision, automated nordicEndotrophin assay complements other collagen biomarkers, advancing comprehensive assessment of the fibro-inflammatory axis in translational and clinical research.

Nordic Bioscience’s assays and services are research use only products and services and do not qualify for medical or diagnostic purposes.