CTX-II
A fragment of cross-linked type II collagen, reflecting cartilage degradation and enabling assessment of joint tissue turnover.
Key features and values
- Urinary assay detecting cross-linked C-terminal telopeptides of type II collagen, indicative of cartilage degradation.
- Reflects type II collagen breakdown, providing insights into cartilage turnover dynamics.
- Validated for use in human urine samples, ensuring reliable and reproducible measurements.
- Non-invasive tool for assessing cartilage degradation, suitable for routine urine sampling.
- Elevated CTX-II levels correlate with increased cartilage degradation in conditions such as osteoarthritis.
- Useful for monitoring therapeutic response, with changes in CTX-II levels reflecting the efficacy of treatments targeting cartilage preservation.
- Facilitates research and development of targeted therapies by providing insights into cartilage degradation mechanisms
Description
The CTX-II biomarker assay is designed to quantify the levels of cross-linked C-terminal telopeptides of type II collagen in urine, serving as a specific indicator of cartilage degradation. Type II collagen is the predominant collagen in articular cartilage, and its degradation releases CTX-II fragments into the urine. By measuring these fragments, the assay provides a direct assessment of cartilage turnover and degradation.
This assay has been validated for use in human urine samples, demonstrating its reliability and reproducibility in various clinical and research settings. Elevated urinary CTX-II levels have been associated with increased cartilage degradation in conditions such as osteoarthritis. The non-invasive nature of the test makes it suitable for routine monitoring of joint health and the effectiveness of therapies aimed at preserving cartilage integrity.
In addition to its clinical applications, the CTX-II assay serves as a valuable tool in research, facilitating the study of cartilage degradation mechanisms and the development of targeted treatments aimed at modulating cartilage turnover processes.
Nordic Bioscience’s assays and services are research use only products and services and do not qualify for medical or diagnostic purposes.
