Biomarkers

A neo-epitope fragment of type II collagen generated by matrix metalloproteinase activity, enabling direct assessment of cartilage degradation and turnover.

A matrix metalloproteinase-generated fragment of type III collagen, reflecting extracellular matrix remodeling and enabling assessment of fibrotic activity.

A fragment of aggrecan from IGD1-2 released by ADAMTS-4/5, enabling non-invasive assessment of cartilage degradation and turnover in joint diseases.

A cross-linked C-terminal telopeptide of type I collagen released during bone resorption, reflecting osteoclastic bone degradation.

A fragment of the N-terminal midregion of osteocalcin, reflecting bone formation activity.

A fragment of the N-terminal propeptide of type IIB fibrillar collagen, enabling non-invasive monitoring of cartilage formation and chondrocyte anabolic activity in joint diseases such as osteoarthritis.

A fragment of the 7S domain of type IV collagen, enabling non-invasive monitoring of basement membrane formation and epithelial extracellular matrix remodeling in fibrotic and inflammatory diseases.