Biomarkers

A neo-epitope fragment of type IV collagen generated by matrix metalloproteinase activity, enabling non-invasive assessment of basement membrane degradation and extracellular matrix remodeling in chronic inflammatory and fibrotic diseases.

A fragment of S100A9 (calprotectin) released by neutrophil elastase measured in blood, enabling precise assessment of active neutrophil-driven inflammation in systemic and tissue-specific conditions.

A neo-epitope fragment of biglycan generated by MMP-9 and MMP-12 activity, reflecting pericellular matrix degradation and extracellular matrix remodeling.

A fragment of glial fibrillary acidic protein cleaved by caspase-6, enabling non-invasive monitoring of astrocytic activation and central nervous system injury.

A structural axonal protein released upon neuronal damage, serving as a sensitive marker for neurodegeneration and axonal injury.

A fragment of nidogen-1 cleaved by cathepsin S, enabling non-invasive monitoring of basement membrane degradation and tumor microenvironment remodeling in cancer.

A matrix metalloproteinase-generated fragment of SPARC, reflecting extracellular matrix remodeling and tissue remodeling activity.

A fragment of type IV collagen α3 chain generated by matrix metalloproteinase activity, enabling non-invasive monitoring of basement membrane remodeling and angiogenic activity in pathological conditions.