Single Joint Tissue Destruction Biomarkers
April 18, 2024
Single joint tissue destruction biomarkers: association between type III collagen degradation and local tissue damage of a single joint
Introduction
The landscape of osteoarthritis (OA) research and therapeutic development has undergone significant transformation, shifting from a primarily structural focus to an emphasis on patient-reported outcomes (PROs). Pain, which primarily originates from the soft tissue of the joint, is intricately linked with the structural integrity of joint tissues. Serological biomarkers are considered potential surrogate endpoints, but their contribution from single joints to systemic levels in OA patients is unclear.
This study explored systemic biomarker levels’ response to tissue damage and healing in patients undergoing knee or hip joint replacement revision for aseptic failure, compared to patients with chronic pain from a joint replacement, but not receiving surgery.
Poster
Conclusion
C3M degradation was found to increase in response to tissue insult to the joint from revision surgery, while no change was observed in a non-surgical group with chronic pain of the joint over 6 months. The increase and gradual decrease throughout the study period indicate a relationship between systemic levels of type III collagen degradation fragments and soft-tissue destruction and inflammation of the joint.