Our focus

Understanding how and why an otherwise ‘tumor-restrictive’ stroma evolves into a ‘tumor-permissive’ stroma. We believe that therapies restoring the tumor restrictive stroma by normalizing ECM turnover are the future of clinical cancer research.  

Our relevance

The hallmark of a ‘tumor-permissive’ stroma is a disruption of tissue microarchitecture and altered extracellular matrix (ECM) remodeling. The ECM alterations in the tumor fuels a vicious cycle of stromal dissemination enriching for cancer-associated fibroblast (CAFs), desmoplasia, immunosuppression and epithelial-to-mesenchymal transition leading to poor efficacy of interventions.

Our current approach

A patient-centric approach to evaluate ECM biomarkers in clinical trials with the potential to predict the likelihood of response and elaborate on MoA by monitoring direct or ‘bystander’ effect on the ECM. In contrast to most other liquid biopsies that focus on circulating tumor DNA (ctDNA) or circulating tumor cells (CSCs), at Nordic Bioscience we focus our biomarker efforts on targeting and quantifying post-translational modifications (PTMs) on proteins or peptide fragments in circulation.


The Protein Fingerprint Technology allows for a tumor agnostic approach (solid tumors) to address tumor microenvironment alterations that can be tracked to specific cellular and biological processes through non-invasive quantification of ECM turnover and with clear value for drug development and benefit for patients. 

The tumor microenvironment
- in a liquid biopsy

Clear value
for drug development

Tumor fibrosis

Predict response

Fibroblast (CAF) activity

Monitor tissue changes

Invasion Metastasis

Pharmacodynamics

Pre-metastatic niche

Mode-of-action

Angiogenesis

Efficacy

Tissue stiffness

Prognosis

Proteolytic activity

Endotyping

Inflammation and
T-cell activity

Stratification

Pro-tumorigenic signaling

 

For the benefit of the patient!

 

Visit our cancer biomarker portfolio and choose a panel that fits your clinical research or drug development targets!

Please don't hesitate to contact us if you have any questions or other inquiries.

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