Rheumatology
RheumaTrace™

Biomarker name
Assay description
Function
C1M
A fragment of type I collagen released by MMP. Fibrillar collagen measuring soft tissue destruction.
Inflammation driven degradation, ECM degradation, Tissue degradation
C2M
A fragment of type II collagen released by MMP. Fibrillar collagen measuring cartilage destruction.
Degradation of cartilage matrix, ECM degradation
C3M
A fragment of type III collagen released by MMP. Fibrillar collagen measuring soft tissue inflammation and destruction.
ECM degradation, Tissue inflammation
C4G
A fragment of type IV collagen released by granzyme-B. Networking forming collagen measuring T-Cell mediated ECM destruction.
T-cell activity, Tissue destruction, ECM degradation, Basement membrane degradation
C4M
A fragment of type IV collagen released by MMP. Network forming collagen measuring basement membrane destruction.
Basement membrane degradation, ECM degradation
CPa9-HNE
A fragment of S100A9 (calprotectin) released by neutrophil elastase. Measures IBD severity and immune status.
Neutrophil activity, Immune Status, Inflammatory Bowel Disease
VICM
A fragment of citrullinated vimentin released by MMP. Measures macrophage activity and immune status.
Macrophage activity, Citrullination

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