Biomarker name
Assay description
Function
ARG
N-terminal epitope of aggrecanase mediated degradation of aggrecan
Cartilage remodeling
C3A
Neo-epitope of ADAMTS-4,5 mediated degradation of type III collagen
Degradation of interstitial matrix and remodeling
C6Ma3
Neo-epitope of MMP-9 mediated degradation of type VI collagen
Interface matrix degradation
COMP-N
A fragment of N-terminal COMP
ECM remodeling
CRPM
Neo-epitope of MMP-mediated degradation c-reactive protein. Measures tissue inflammation in the affected tissue.
Tissue inflammation
Osteocalcin
Osteocalcin
Bone formation
PRO-C3X
Cross-linked N-terminal pro-peptide of type III collagen
ECM cross-linking
T2CM
Neo-epitope of MMP-1 and MMP-13 mediated degradation of type II collagen
Cartilage and fibrocartilage degradation and remodeling

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