Dermatology

Biomarker name
Assay description
Function
C10C
A fragment of type X collagen released by cathepsin K
Endochondral bone remodeling, ECM degradation
C1M
A fragment of type I collagen released by MMP. Fibrillar collagen measuring soft tissue destruction.
Inflammation driven degradation, ECM degradation, Tissue degradation
C2M
A fragment of type II collagen released by MMP. Fibrillar collagen measuring cartilage destruction.
Degradation of cartilage matrix, ECM degradation
C3M
A fragment of type III collagen released by MMP. Fibrillar collagen measuring soft tissue inflammation and destruction.
ECM degradation, Tissue inflammation
C4M
A fragment of type IV collagen released by MMP. Network forming collagen measuring basement membrane destruction.
Basement membrane degradation, ECM degradation
C5M
A fragment of type V collagen released by MMP-2,9
Degradation of interstitial matrix and remodeling, ECM degradation
C6A6
A fragment of C-terminal type VIa6 collagen. Linked to skin diseases.
ECM turnover, Skin tissue turnover
C6M
A fragment of type VIa1 collagen released by MMP-2. Special beaded filament collagen measuring interstitial ECM destruction.
Interface matrix degradation
C7M
A fragment of type VII collagen released by MMP-2,9,13. The only anchoring fibril, measuring dermal-epidermal and gut tissue destruction.
Degradation of anchoring fibrils, ECM degradation, Tissue destruction
CPa9-HNE
A fragment of S100A9 (calprotectin) released by neutrophil elastase. Measures IBD severity and immune status.
Neutrophil activity, Immune Status, Inflammatory Bowel Disease
PRO-C1
A fragment of N-terminal type I collagen
Bone formation, ECM formation
PRO-C3 (nordicPRO-C3™)
A fragment of N-terminal type III collagen. Fibrillar collagen measuring fibroblast formation of interstitial ECM and fibrosis.
Fibrogenesis, ECM formation, Fibrosis
PRO-C4
A fragment of the internal 7S domain of type IV collagen. Networking forming collagen measuring epithelial cell mediated basement membrane formation.
Basement membrane synthesis, ECM formation
PRO-C6 (nordicPRO-C6™)
A fragment of C-terminal type VIa3 collagen (Endotrophin). Measures highly activated fibroblasts, linking ECM and wound healing.
Pro-fibrotic signaling, ECM formation, Wound healing
VICM
A fragment of citrullinated vimentin released by MMP. Measures macrophage activity and immune status.
Macrophage activity, Citrullination
CRPM
Neo-epitope of MMP-mediated degradation c-reactive protein. Measures tissue inflammation in the affected tissue.
Tissue inflammation
PRO-C17
A fragment of C-terminal type XVII collagen. Membrane bound collagen linked to skin diseases.
ECM formation, Epithelial damage, Skin tissue turnover
PRO-C22
C-terminal of type XXII collagen, neoepitope specific. FACIT collagen measuring tissue formation, molecular bridging and tissue organization.
Connective tissue formation, FACIT collagen, Molecular bridging
PRO-C7
A fragment of C-terminal type VII collagen. The only anchoring fibril, measuring skin and intestinal tissue formation.
ECM formation, Intestinal matrix turnover, Skin tissue turnover

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