Renal diseases

Biomarker name
Assay description
Function
C3M
A fragment of type III collagen released by MMP. Fibrillar collagen measuring soft tissue inflammation and destruction.
ECM degradation, Tissue inflammation
CTX-III (nordicCTX-III™)
A fragment of degraded crosslinked type III collagen. Measures fibrosis resolution.
Fibrosis resolution
PRO-C3 (nordicPRO-C3™)
A fragment of N-terminal type III collagen. Fibrillar collagen measuring fibroblast formation of interstitial ECM and fibrosis.
Fibrogenesis, ECM formation, Fibrosis
PRO-C6 (nordicPRO-C6™)
A fragment of C-terminal type VIa3 collagen (Endotrophin). Measures highly activated fibroblasts, linking ECM and wound healing.
Pro-fibrotic signaling, ECM formation, Wound healing
TUM
A fragment of type IV collagen released by MMP-2, 9
Signaling peptide of the basement membrane, ECM degradation
LG3
LG3 domain liberated by BMP1 from Perlecan
ECM degradation
Endotrophin (ETP)
The full 77 AA fibroblast hormone Endotrophin, part of type VI collagen. Measures fibro-inflammation and systemic/metabolic inflammation.
Endotrophin;, Fibro-inflammation, Systemic Inflammation
LG1M
Neo-epitope of MMP-9 mediated degradation of laminin gamma 1 chain
Basement membrane degradation

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