Hepatic diseases

Biomarker name
Assay description
Function
C3M
A fragment of type III collagen released by MMP. Fibrillar collagen measuring soft tissue inflammation and destruction.
ECM degradation, Tissue inflammation
C4M
A fragment of type IV collagen released by MMP. Network forming collagen measuring basement membrane destruction.
Basement membrane degradation, ECM degradation
C5M
A fragment of type V collagen released by MMP-2,9
Degradation of interstitial matrix and remodeling, ECM degradation
C6M
A fragment of type VIa1 collagen released by MMP-2. Special beaded filament collagen measuring interstitial ECM destruction.
Interface matrix degradation
CTX-III (nordicCTX-III™)
A fragment of degraded crosslinked type III collagen. Measures fibrosis resolution.
Fibrosis resolution
PRO-C3 (nordicPRO-C3™)
A fragment of N-terminal type III collagen. Fibrillar collagen measuring fibroblast formation of interstitial ECM and fibrosis.
Fibrogenesis, ECM formation, Fibrosis
PRO-C4
A fragment of the internal 7S domain of type IV collagen. Networking forming collagen measuring epithelial cell mediated basement membrane formation.
Basement membrane synthesis, ECM formation
PRO-C5
A fragment of C-terminal type V collagen. Fibrillar collagen measuring myofibroblasts, CAFs and hepatic fibrosis.
ECM formation, Cancer-Associated Fibroblast (CAF), Hepatic Fibrosis
PRO-C6 (nordicPRO-C6™)
A fragment of C-terminal type VIa3 collagen (Endotrophin). Measures highly activated fibroblasts, linking ECM and wound healing.
Pro-fibrotic signaling, ECM formation, Wound healing
PRO-C8
A fragment of C-terminal type VIII collagen. Networking forming collagen measuring epithelial cell formation.
Signaling peptide of the basement membrane, ECM formation, Epithelial formation
Endotrophin (ETP)
The full 77 AA fibroblast hormone Endotrophin, part of type VI collagen. Measures fibro-inflammation and systemic/metabolic inflammation.
Endotrophin;, Fibro-inflammation, Systemic Inflammation
PRO-C18L
N-terminal of the type XVIII collagen medium and long isoforms
Basement membrane degradation and remodeling

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