Cardiovascular diseases

Biomarker name
Assay description
Function
C1M
A fragment of type I collagen released by MMP. Fibrillar collagen measuring soft tissue destruction.
Inflammation driven degradation, ECM degradation, Tissue degradation
C3M
A fragment of type III collagen released by MMP. Fibrillar collagen measuring soft tissue inflammation and destruction.
ECM degradation, Tissue inflammation
C4M
A fragment of type IV collagen released by MMP. Network forming collagen measuring basement membrane destruction.
Basement membrane degradation, ECM degradation
CTX-III (nordicCTX-III™)
A fragment of degraded crosslinked type III collagen. Measures fibrosis resolution.
Fibrosis resolution
PRO-C3 (nordicPRO-C3™)
A fragment of N-terminal type III collagen. Fibrillar collagen measuring fibroblast formation of interstitial ECM and fibrosis.
Fibrogenesis, ECM formation, Fibrosis
PRO-C6 (nordicPRO-C6™)
A fragment of C-terminal type VIa3 collagen (Endotrophin). Measures highly activated fibroblasts, linking ECM and wound healing.
Pro-fibrotic signaling, ECM formation, Wound healing
PRO-C8
A fragment of C-terminal type VIII collagen. Networking forming collagen measuring epithelial cell formation.
Signaling peptide of the basement membrane, ECM formation, Epithelial formation
TUM
A fragment of type IV collagen released by MMP-2, 9
Signaling peptide of the basement membrane, ECM degradation
Endotrophin (ETP)
The full 77 AA fibroblast hormone Endotrophin, part of type VI collagen. Measures fibro-inflammation and systemic/metabolic inflammation.
Endotrophin;, Fibro-inflammation, Systemic Inflammation
TIM
Neo-epitope of MMP-12 mediated degradation of titin (Cardiac isoform)
Cardiac remodeling

You need to select at least 1 biomarker.