Gastroenterology

Biomarker name
Assay description
Function
C1M
A fragment of type I collagen released by MMP. Fibrillar collagen measuring soft tissue destruction.
Inflammation driven degradation, ECM degradation, Tissue degradation
C3M
A fragment of type III collagen released by MMP. Fibrillar collagen measuring soft tissue inflammation and destruction.
ECM degradation, Tissue inflammation
C4A4-HNE
A fragment of the alpha-4 chain of type IV collagen generated by human neutrophil elastase (HNE). Networking forming collagen measuring neutrophil activity.
Mucosal inflammation, Neutrophil activity
C4G
A fragment of type IV collagen released by granzyme-B. Networking forming collagen measuring T-Cell mediated ECM destruction.
T-cell activity, Tissue destruction, ECM degradation, Basement membrane degradation
C4M
A fragment of type IV collagen released by MMP. Network forming collagen measuring basement membrane destruction.
Basement membrane degradation, ECM degradation
CPa9-HNE
A fragment of S100A9 (calprotectin) released by neutrophil elastase. Measures IBD severity and immune status.
Neutrophil activity, Immune Status, Inflammatory Bowel Disease
CTX-III (nordicCTX-III™)
A fragment of degraded crosslinked type III collagen. Measures fibrosis resolution.
Fibrosis resolution
ELP-3
Neo-epitope of proteinase-3 mediated degradation of elastin. Marker of ECM degradation and neutrophil activation and degranulation.
Stromal reactivity, Elastin, Neutrophil activity, ECM degradation
PRO-C3 (nordicPRO-C3™)
A fragment of N-terminal type III collagen. Fibrillar collagen measuring fibroblast formation of interstitial ECM and fibrosis.
Fibrogenesis, ECM formation, Fibrosis
PRO-C4
A fragment of the internal 7S domain of type IV collagen. Networking forming collagen measuring epithelial cell mediated basement membrane formation.
Basement membrane synthesis, ECM formation
PRO-C6 (nordicPRO-C6™)
A fragment of C-terminal type VIa3 collagen (Endotrophin). Measures highly activated fibroblasts, linking ECM and wound healing.
Pro-fibrotic signaling, ECM formation, Wound healing
VICM
A fragment of citrullinated vimentin released by MMP. Measures macrophage activity and immune status.
Macrophage activity, Citrullination
C6Ma3
Neo-epitope of MMP-9 mediated degradation of type VI collagen
Interface matrix degradation
PRO-C11
A fragment of N-terminal type XI collagen. Fibrillar collagen measuring tissue formation, myofibroblasts and cancer-associated fibroblasts (CAFs)
Fibrogenesis, ECM formation, Cancer-Associated Fibroblast (CAF)
PRO-C16
C-terminal of Type XVI collagen. FACIT collagen measuring tissue formation.
Intestinal matrix turnover, FACIT collagen
PRO-C17
A fragment of C-terminal type XVII collagen. Membrane bound collagen linked to skin diseases.
ECM formation, Epithelial damage, Skin tissue turnover
PRO-C22
C-terminal of type XXII collagen. FACIT collagen measuring tissue formation, molecular bridging and tissue organization.
Connective tissue formation, FACIT collagen, Molecular bridging
PRO-C7
A fragment of C-terminal type VII collagen. The only anchoring fibril, measuring skin and intestinal tissue formation.
ECM formation, Intestinal matrix turnover, Skin tissue turnover

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