Find an abstract and a link to most of the publications produced by Nordic Bioscience
Cardiovascular Disease (CVD) is the most common cause of death in industrialized countries, and myocardial infarction (MI) is a major CVD with significant morbidity and mortality. Following MI, the left ventricle (LV) undergoes a wound healing response to ischemia that results in extracellular matri...
December 14, 2017
Journal:
Matrix Biol
Author:
Nielsen SH, Mouton AJ, DeLeon-Pennell KY, Genovese F, Karsdal MA, Lindsey ML
Renal fibrosis is the central pathogenic process in progression of chronic kidney disease (CKD). Collagen type VI (COL VI) is upregulated in renal fibrosis. Endotrophin is released from COL VI and promotes pleiotropic pro-fibrotic effects. Kidney disease severity varies considerably and accurate inf...
December 1, 2017
Journal:
Scientific Reports, Nature
Author:
Fenton A, Jesky M, Boor P, Tepel M, Karsdal MA, Genovese F, Cockwell P, Ferro CJ, Rasmussen DGK
AIM: Peripheral artery disease (PAD) is a common manifestation of systemic atherosclerosis affecting peripheral arteries. The underlying pathology of PAD are disorganized extracellular matrix (ECM), caused by inflammation and oxidation. Previous studies have demonstrated an important structure disor...
August 12, 2017
Journal:
Atherosclerosis
Author:
Aguilera AH, Nielsen SH, Fernández-Arroyo S, Martín-Paredero V, Karsdal MA, Genovese F, Camps J, Joven J
ZSF1 rats exhibit spontaneous nephropathy secondary to obesity, hypertension, and diabetes, and have gained interest as a model system with potentially high translational value to progressive human disease. To thoroughly characterize this model, and to better understand how closely it recapitulates ...
July 26, 2017
Journal:
PLoS One
Author:
Dower K, Zhao S, Schlerman FJ, Savary L, Campanholle G, Johnson BG, Xi L, Nguyen V, Zhan Y, Lech MP, Wang J, Nie Q, Karsdal MA, Genovese F, Boucher G, Brown TP, Zhang B, Homer BL, Martinez RV
Kidney allograft failure due to chronic injury/rejection remains the main cause of graft loss in renal transplant recipients (RTR). Here, we investigated whether specific biomarkers of extracellular matrix (ECM) turnover are associated with allograft function and chronic kidney disease (CKD) stage i...
April 21, 2017
Journal:
PLoS One
Author:
Stribos EGD, Nielsen SH, Brix S, Karsdal MA, Seelen MA, van Goor H, Bakker SJL, Olinga P, Mutsaers HAM, Genovese F
Background: Patients with chronic kidney disease (CKD) are at increased risk of end-stage renal disease (ESRD) and early mortality. The underlying pathophysiological processes are not entirely understood but may include dysregulation of extracellular matrix formation with accelerated systemic and re...
March 20, 2017
Journal:
J Transl Med.
Author:
Hijmans RS, Yazdani S, Navis G, van Goor H, Karsdal MA, Genovese F, van den Born J, Rasmussen DGK
A high level of extracellular matrix (ECM) turnover characterizes several lung diseases with fibrotic features. Type III collagen is one of the most abundant collagens in lung parenchyma, and cathepsins play a role in lung pathology, being responsible for tissue remodeling. In this study, we explore...
Search and find publications that we have published.
Please don't hesitate to contact us if you have any questions or other inquiries.