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BACKGROUND: Abdominal aortic calcifications (AAC) predict cardiovascular mortality. A new scoring model for AAC, the Morphological Atherosclerotic Calcification Distribution (MACD) index may contribute with additional information to the commonly used Aortic Calcification Severity (AC24) score, when ...
December 20, 2011
Journal:
BMC Cardiovasc Disord
Author:
Barascuk N, Ganz M, Nielsen M, Register TC, Rasmussen LM, Karsdal MA, Christiansen C
Aim: Arterial extracellular matrix (ECM) remodeling by matrix metalloproteinases (MMPs) is one of the major hallmarks of atherosclerosis. Mimecan, also known as osteoglycin has been implicated in the integrity of the ECM. This study assessed the validity of an enzyme-linked immunosorbent assay (EL...
June 11, 2011
Journal:
Biomarker Insights
Author:
Barascuk N, Vassiliadis E, Zheng Q, Wang Y, Wang W, Larsen L, Rasmussen LM, Karsdal MA
Objective: Degradation of collagen in the arterial wall by matrix metalloproteinases is the hallmark of atherosclerosis. We have developed an ELISA for the quantification of type III collagen degradation mediated by MMP-9 in urine. Design and methods: A monoclonal antibody targeting a specific MMP-9...
April 30, 2011
Journal:
Clin Biochem
Author:
Barascuk N, Vassiliadis E, Larsen L, Wang J, Zheng Q, Xing R, Cao Y, Crespo C, Lapret I, Sabatini M, Cilleneuve N, Vilaine JP, Rasmussen LM, Register TC, Karsdal MA
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