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Summary: Early prognosis of osteoporosis risk is not only important to individual patients but is also a key factor when screening for osteoporosis drug trial populations. We present an osteoporosis fracture risk score based on vertebral heights. The score separated individuals who sustained fractur...
July 22, 2011
Journal:
Osteoporos Int.
Author:
Lillholm M, Ghosh A, Pettersen PC, de Bruijne M, Dam EB, Karsdal MA, Christiansen C, Genant HK, Nielsen M
Anti-resorptive strategies may affect bone collagen maturation differently depending on the mode of action. Orally administrated calcitonin resulted in a dose dependent inhibition of bone resorption but did not change bone collagen maturation. This may reflect aspects of bone quality. INTRODUCTION:...
September 19, 2008
Journal:
Osteoporos Int.
Author:
Karsdal MA, Byrjalsen I, Leeming DJ, Delmas PD, Christiansen C
We investigated whether the age of the bones endogenously exerts control over the bone resorption ability of the osteoclasts, and found that osteoclasts preferentially develop and resorb bone on aged bone. These findings indicate that the bone matrix itself plays a role in targeted remodeling of age...
June 18, 2007
Journal:
Osteoporos Int.
Author:
Henriksen K, Leeming DJ, Byrjalsen I, Nielsen RH, Sorensen MG, Dziegiel MH, Martin TJ, Christiansen C, Karsdal MA
Numerous experimental and clinical observations suggest that overall changes in bone resorption during menopause or treatment with hormone replacement therapy (HRT) are combined effects of changes in osteoclast number and function. Moreover, due to a coupling between osteoclastic bone resorption and...
May 18, 2007
Journal:
Osteoporos Int.
Author:
Henriksen K, Tankó LB, Qvist P, Delmas PD, Christiansen C, Karsdal MA
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