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ClC-7, located in late endosomes and lysosomes, is critical for the function of osteoclasts. Secretion of Cl(-) by the ruffled border of osteoclasts enables H(+) secretion by v-H(+)-ATPases to dissolve bone mineral. Mice lacking ClC-7 show altered lysosomal function that leads to severe lysosomal st...
September 8, 2015
Journal:
Cell Tissue Res.
Author:
Guo J, Bervoets TJ, Henriksen K, Everts V, Bronckers AL
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