Find an abstract and a link to most of the publications produced by Nordic Bioscience
There is a need for antidiabetic agents successfully targeting insulin sensitivity and treating obesity control at the same time. The aim of this first-in-human study was (a) to evaluate safety and tolerability, (b) to evaluate pharmacokinetics and (c) to assess indications of receptor engagement of...
May 21, 2021
Journal:
Br J Clin Pharmacol
Author:
Henriksen K, Broekhuizen K, de Boon MIW, Karsdal MA, Christiansen C, Dillingh RM, de Kam M, Kumar R, Burggraaf J, Kamerling MCI, Bihlet AR
BACKGROUND: Excessive extracellular matrix (ECM) remodeling and a reactive stroma can affect T-cell infiltration and T-cell activity in the tumor and hereby influence response to immune checkpoint inhibitors (ICI). In the pursuit of finding biomarkers that predict treatment response, we evaluated th...
December 19, 2018
Journal:
Br J Clin Pharmacol
Author:
Jensen C, Madsen DH, Hansen M, Schmidt H, Svane IM, Karsdal MA, Willumsen N
Amylin and GLP-1 agonism induce a well-known anorexic effect at dose initiation, which is managed by dose escalation. In this study we investigated how to optimize tolerability while maintaining efficacy of a novel, highly potent dual amylin and calcitonin receptor agonist (DACRA), KBP-089. Furtherm...
January 21, 2017
Journal:
Br J Clin Pharmacol
Author:
Gydesen S, Hjuler ST, Freving Z, Andreassen KV, Sonne N, Hellgren LI, Karsdal MA, Henriksen K
OBJECTIVE: In this study, KBP-042, a dual amylin- and calcitonin-receptor agonist, was investigated as a treatment of obesity and insulin resistance in five different doses (0.625 µg/kg-10 µg/kg) compared with saline-treated and pair-fed controls. METHODS: Rats with obesity received daily s.c. admi...
August 1, 2016
Journal:
Br J Clin Pharmacol
Author:
Hjuler ST, Gydesen S, Andreassen KV, Pedersen SL, Hellgren LI, Karsdal MA, Henriksen K
The oral delivery of peptides and proteins has been hampered by an array of obstacles. However, several promising novel oral delivery systems have been developed. This paper reviews the most advanced oral formulation technologies, and highlights key lessons and implications from studies undertaken t...
May 1, 2015
Journal:
Br J Clin Pharmacol
Author:
Karsdal MA, Riis BJ, Mehta N, Stern W, Arbit E, Christiansen C, Henriksen K
AIM:The aim of this project was to perform an empirical evaluation of the impact of on site source data verification (SDV) on the data quality in a clinical trial database to guide an informed decision on selection of the monitoring approach. METHODS:We used data from three randomized phase III tri...
October 19, 2014
Journal:
Br J Clin Pharmacol
Author:
Andersen JR, Byrjalsen I, Bihlet AR, Kalakou F, Hoeck HC, Hansen G, Hansen HB, Karsdal MA, Riis BJ
Aims: To investigate the influence of food intake on the bioavailability and pharmacodynamic effects of salmon calcitonin (sCT). Methods: A single-blind, randomized, partly placebo-controlled study was conducted in 36 healthy postmenopausal female volunteers aged 62-74 years. The influence of food ...
April 4, 2009
Journal:
Br J Clin Pharmacol
Author:
Karsdal MA, Byrjalsen I, Azria M, Arnold M, Choi L, Riis BJ, Christiansen C
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