Publications
Find an abstract and a link to most of the publications produced by Nordic Bioscience
Background: Rupture of atherosclerotic plaques is the major cause of acute cardiovascular events. The biomarker PRO-C6 measuring Endotrophin, a matrikine of collagen type VI, may provide valuable information detecting subjects in need of intensified strategies for secondary prevention. Objective: I...
May 5, 2021
Journal:
J Intern Med
Author:
Holm Nielsen S, Edsfeldt A, Tengryd C, Gustafsson H, Shore CA, Natali A, Khan F, Bengtsson E, Karsdal MA, Leeming DJ, Nilsson J, Goncalves I, Genovese F
Background and aims: A vulnerable plaque is an atherosclerotic plaque that is rupture-prone with a higher risk to cause cardiovascular symptoms such as myocardial infarction or stroke. Mimecan or osteoglycin is a small leucine-rich proteoglycan, important for collagen fibrillogenesis, that has been ...
November 25, 2020
Journal:
atherosclerosis
Author:
Tengryd C, Nielsen SH, Cavalera M, Bengtsson E, Genovese F, Dunér P, Orho-Melander M, Nilsson J, Edsfeldt A, Gonçalves I, Karsdal MA
Background: Patients with atherosclerosis have a high risk of cardiovascular events and death. Atherosclerosis is characterized by accumulation of lipids, cells and extracellular matrix proteins in the intima. We hypothesized that dysregulated remodeling of the basement membrane proteins may be asso...
November 6, 2018
Journal:
J am heart assoc
Author:
Nielsen SH, Tengryd C, Edsfeldt A, Brix S, Genovese F, Bengtsson E, Karsdal MA, Leeming DJ, Nilsson J, Goncalves I
OBJECTIVE: Atherosclerosis is characterized by accumulation of lipids, cells and extracellular matrix (ECM) proteins in the arterial wall. Collagen type I (COL1), a component of the arterial ECM, is cleaved by matrix metalloproteinases (MMPs) and known to be remodelled in atherosclerosis. We explore...
August 28, 2018
Journal:
J Intern Med
Author:
Holm Nielsen S, Tengryd C, Edsfeldt A, Genovese F, Bengtsson E, Karsdal MA, Leeming DJ, Nilsson J, Goncalves I
AIM: Collagens are major cardiac extracellular matrix components, known to be actively remodelled and accumulated during diffuse myocardial fibrosis. We evaluated whether accelerated collagen turnover described by neo-epitope biomarkers reflecting collagen formation and degradation separates patient...
May 25, 2018
Journal:
Eur J Prev Cardiol
Author:
Nielsen SH, Mygind ND, Michelsen MM, Bechsgaard DF, Suhrs HE, Genovese F, Brix S, Karsdal MA, Prescott E, Kastrup J, Nielsen Bay H
BACKGROUND: The prevalence of lower extremity artery disease (LEAD) is high (20%-25%) in the population older than 65 years, but patients are seldom identified until the disease is advanced. Circulating markers of disease activity might provide patients with a key opportunity for timely treatment. W...
March 31, 2018
Journal:
J Vasc Surg
Author:
Hernández-Aguilera A, Nielsen SH, Bonache C, Fernández-Arroyo S, Martín-Paredero V, Fibla M, Karsdal MA, Genovese F, Menendez JA, Camps J, Joven J
AIM: Peripheral artery disease (PAD) is a common manifestation of systemic atherosclerosis affecting peripheral arteries. The underlying pathology of PAD are disorganized extracellular matrix (ECM), caused by inflammation and oxidation. Previous studies have demonstrated an important structure disor...
August 12, 2017
Journal:
Atherosclerosis
Author:
Aguilera AH, Nielsen SH, Fernández-Arroyo S, Martín-Paredero V, Karsdal MA, Genovese F, Camps J, Joven J
Elastin is a signature protein of the arteries and lungs, thus it was hypothesized that elastin is subject to enzymatic degradation during cardiovascular and pulmonary diseases. The aim was to investigate if different fragments of the same protein entail different information associated to two diffe...
June 21, 2013
Journal:
PLoS One
Author:
Skjøt-Arkil H, Clausen RE, Rasmussen LM, Wang W, Wang Y, Zheng Q, Mickley H, Saabye L, Diederichsen ACP, Lambrechtsen J, Martinez FJ, Hogaboam CM, Han M, Larsen MR, Nawrocki A, Vainer B, Krustrup D, Bjørling-Poulsen M, Karsdal MA, Leeming DJ
Extracellular matrix remodelling is a prerequisite for plaque rupture in atherosclerotic lesion. Versican, an extracellular matrix proteoglycan present in normal and atherosclerotic arteries is a substrate for matrix metalloproteinases (MMPs) present in macrophage rich areas. The aim of the current ...
June 3, 2013
Journal:
Int J Clin Exp Med.
Author:
Barascuk N, Genovese F, Larsen L, Byrjalsen I, Zheng Q, Sun S, Hosbond S, Poulsen TS, Jensen JM, Mickley H, Register TC, Rasmussen LM, Leeming DJ, Christiansen C, Karsdal MA, Diederichsen ACP
BACKGROUND: Abdominal aortic calcifications (AAC) predict cardiovascular mortality. A new scoring model for AAC, the Morphological Atherosclerotic Calcification Distribution (MACD) index may contribute with additional information to the commonly used Aortic Calcification Severity (AC24) score, when ...
December 20, 2011
Journal:
BMC Cardiovasc Disord
Author:
Barascuk N, Ganz M, Nielsen M, Register TC, Rasmussen LM, Karsdal MA, Christiansen C
Search and find publications that we have published.
Please don't hesitate to contact us if you have any questions or other inquiries.
