Author

Journal

Background: Therapies for metabolic diseases are numerous, yet improving insulin sensitivity beyond that induced by weight loss remains challenging. Therefore, search continues for novel treatment candidates that can stimulate insulin sensitivity and increase weight loss efficacy in combination with...

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November 20, 2020

Journal:
Review

Author:
Sonne N, Karsdal MA, Henriksen K.

Connective tissue (ConT) remodeling is an essential process in tissue regeneration, where a balanced replacement of old tissue by new tissue occurs. This balance is disturbed in chronic diseases, often autoimmune diseases, usually resulting in the buld up of fibrosis and a gradual loss of organ func...

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PURPOSE OF REVIEW: Biomarkers of remodeling represent a loose collection of features referring to several biological adaptations of the lung to cope with stressing factors. In addition, remodelling infers a dynamic process that would require a spatiotemporal resolution. This review focuses on differ...

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January 26, 2020

Journal:
Curr Opin Pulm Med

Author:
Bahmer T, Sand JM, Weckmann M

Usually the dense extracellular structure in fibrotic tissues is described as extracellular matrix (ECM) or simply as collagen. However, fibrosis is not just fibrosis, which is already exemplified by the variant morphological characteristics of fibrosis due to viral versus cholestatic, autoimmune or...

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This review discusses the role of extracellular matrix (ECM) quality in the pathogenesis of pulmonary fibrosis (PF). In PF, the highly ordered structure of collagens and elastin within the ECM of the lung is severely disrupted and lacks its original tissue quality. Discussions about the ECM have foc...

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