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Objective: We investigated the effects of tocilizumab (TCZ) on joint tissue remodeling in patients with moderate to severely active RA by measuring tissue-specific biomarker. Methods: The LITHE biomarker study (n = 740) was a phase III study of 4- and 8-mg/kg TCZ in combination with MTX. Early resp...
February 5, 2014
Journal:
Semin Arthritis Rheum
Author:
Bay-Jensen AC, Platt A, Byrjalsen I, Christiansen C, Karsdal MA, Vergnaud P
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease associated with potentially debilitating joint inflammation, as well as altered skeletal bone metabolism and co-morbid conditions. Early diagnosis and aggressive treatment to control disease activity offers the highest likelihood of ...
April 8, 2011
Journal:
Arthritis Res Ther
Author:
Karsdal MA, Woodworth T, Henriksen K, Maksymowych WP, Vergnaud P, Christiansen C, Schubert T, Qvist P, Schett G, Platt A, Bay-Jensen AC, Genant HK
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