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BACKGROUND: We aimed to investigate the prognostic value of two biomarkers of tissue inflammation, matrix metalloproteinase-dependent degradation of C-reactive protein (CRPM) and connective tissue type I collagen turnover (C1M), on the incidence and progression of radiographic osteoarthritis (OA) in...
April 1, 2016
Arthritis Res Ther
Saberi Hosnijeh F, Siebuhr AS, Uitterlinden AG, Oei EH, Hofman A, Karsdal MA, Bierma-Zeinstra SM, Bay-Jensen AC, van Meurs JB
BACKGROUND:Research for the use of biomarkers in osteoarthritis (OA) is promising, however, adequate discrimination between patients and controls may be hampered due to innate differences. We set out to identify loci influencing levels of serum cartilage oligomeric protein (sCOMP) and urinary C-telo...
July 23, 2014
J Med Genet
Ramos YF, Metrustry S, Arden NK, Bay-Jensen AC, Beekman M, de Craen AJ, Cupples LA, Esko T, Evangelou E, Felson DT, Hart DJ, Ioannidis JP, Karsdal MA, Kloppenburg M, Lafeber F, Metspalu A, Panoutsopoulou K, Slagboom PE, Spector TD, van Spil EW, Uitterlinden AG, Zhu Y, Valdes AM, van Meurs JB, Meulenbelt I
Objective: To evaluate the role of three cartilage-derived biomarkers on osteoarthritis (OA): urinary C-terminal telopeptide (uCTX-II), serum cartilage oligomeric protein (sCOMP), and serum MMP degraded type II collagen (sC2M). Subjects and methods: Samples from 3582 individuals from the Rotterdam ...
May 22, 2014
Meulenbelt I, Chassaing E, Arden NK, Bierma-Zeinstra SM, Hart D, Hofman A, Karsdal MA, Kloppenburg M, Kroon HM, Slagboom PE, Spector TD, Uitterlinden AG, van Meurs JB, Bay-Jensen AC, Valdes AM
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