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Chronic obstructive pulmonary disease (COPD) is characterized by a slow heterogeneous progression. Therefore, improved biomarkers that can accurately identify patients with the highest likelihood of progression and therefore the ability to benefit from a given treatment, are needed. Elastin is an es...
March 11, 2020
Journal:
Sci Rep
Author:
Rønnow S, Langholm LL, Leeming DJ, Manon-Jensen T, Miller BE, Karsdal MA, Vestbo J, Thal-Singer R, Thoracius-Ussing J, Bülow Sand JM
PURPOSE: Elastin is a signature protein of lungs. Increased elastin turnover driven by altered proteolytic activity is an important part of lung tumorigenesis. Elastin-derived fragments have been shown to be pro-tumorigenic, however, little is known regarding the biomarker potential of such elastin ...
November 22, 2018
Journal:
Journal Of Cancer Research And Clinical Oncology
Author:
Thoracius-Ussing J, Kehlet SN, Rønnow S, Karsdal MA, Willumsen N
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