Publications
Find an abstract and a link to most of the publications produced by Nordic Bioscience
Find an abstract and a link to most of the publications produced by Nordic Bioscience
Background: Chronic obstructive pulmonary disease (COPD) is characterized by abnormal epithelial repair resulting in a hypercoagulable state with intra-alveolar accumulation of fibrin and alveolar basement membrane destruction. This study aimed to investigate if the combination of two serological bi...
November 19, 2020
Journal:
Lancet Respir Med
Author:
Langholm LL, Karsdal MA, Manon-Jensen T, Miller BE, Vestbo J, Leeming DJ, Thal-Singer R, Bülow Sand JM, Rønnow S
Background: Lung epithelial damage, activation of the wound healing cascade, and remodeling of the extracellular matrix (ECM) play a major role in chronic obstructive pulmonary disease (COPD). The pro-peptide of type VI collagen has been identified as the hormone endotrophin. Endotrophin has been sh...
July 30, 2020
Journal:
Respir Res.
Author:
Rønnow S, Langholm LL, Karsdal MA, Manon-Jensen T, Miller BE, Vestbo J, Leeming DJ, Bülow Sand JM, Thal-Singer R
Chronic obstructive pulmonary disease (COPD) is characterized by a slow heterogeneous progression. Therefore, improved biomarkers that can accurately identify patients with the highest likelihood of progression and therefore the ability to benefit from a given treatment, are needed. Elastin is an es...
March 11, 2020
Journal:
Sci Rep
Author:
Rønnow S, Langholm LL, Leeming DJ, Manon-Jensen T, Miller BE, Karsdal MA, Vestbo J, Thal-Singer R, Thoracius-Ussing J, Bülow Sand JM
Background: Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and lung tissue deterioration. Given the high vascularity of the lung, von Willebrand factor (VWF), a central component of wound healing initiation, has previously been assessed in COPD. VWF processing,...
March 9, 2020
Journal:
Int J Chron Obstruct Pulmon
Author:
Langholm LL, Rønnow S, Leeming DJ, Miller BE, Vestbo J, Karsdal MA, Manon-Jensen T, Bülow Sand JM, Thal-Singer R
Background: Chronic obstructive pulmonary disease (COPD) is characterized by abnormal epithelial repair process that may result in intra-airway accumulation of fibrin. Given that plasma fibrinogen is the only FDA approved biomarker that predicts mortality and COPD exacerbations, we hypothesized that...
December 2, 2019
Journal:
Lancet Respir Med
Author:
Manon-Jensen T, Langholm LL, Karsdal MA, Vestbo J, Leeming DJ, Miller BE, Thal-Singer R, Bülow Sand JM, Rønnow S
BACKGROUND: Change in forced expiratory volume in one second (FEV1) is important for defining severity of chronic obstructive pulmonary disease (COPD). Serological neoepitope markers of collagen turnover may predict rate of change in FEV1. METHODS: One thousand COPD subjects from the observational,...
December 4, 2017
Journal:
BMC Pulm Med.
Author:
Leeming DJ, Byrjalsen I, Bihlet AR, Lange P, Miller BE, Karsdal MA, Vestbo J, Thal-Singer R, Bülow Sand JM
BACKGROUND: There is a need to identify individuals with COPD at risk for disease progression and mortality. Lung tissue remodeling is associated with the release of extracellular matrix (ECM) fragments into the peripheral circulation. We hypothesized that ECM remodeling was associated with mortalit...
October 4, 2016
Journal:
Respir Res.
Author:
Leeming DJ, Byrjalsen I, Bihlet AR, Lange P, Miller BE, Karsdal MA, Vestbo J, Thal-Singer R, Bülow Sand JM
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