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Diabetic kidney disease is a worldwide epidemic, and therapies are incomplete. Clinical data suggest that improved renal outcomes by Na+-glucose cotransporter 2 inhibitor (SGLT2i) are partly beyond their antihyperglycemic effects; however, the mechanisms are still elusive. Here, we investigated the ...
April 1, 2020
Journal:
AM J Physiol Renal Physiol
Author:
Hodrea J, Balogh DB, Hosszu A, Lenart L, Besztercei B, Sparding N, Genovese F, Wagner LJ, Szabo AJ, Fekete A, Koszegi S
KEY POINTS: Increased activation of the renin-angiotensin-aldosterone system (RAAS) and elevated growth factor production are of crucial importance in the development of renal fibrosis leading to diabetic kidney disease. The aim of this study was to provide evidence for the antifibrotic potential of...
January 17, 2019
Journal:
Am J Physiol Endocrinol Metab
Author:
Molnar A, Lenart L, Hodrea J, Balogh DB, Lakat T, Szkibinszjik J, Sparding N, Genovese F, Wagner L, Vannay A, Szabo AJ, Fekete A, Koszegi S, Hosszu A
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