Find an abstract and a link to most of the publications produced by Nordic Bioscience
BACKGROUND:Research for the use of biomarkers in osteoarthritis (OA) is promising, however, adequate discrimination between patients and controls may be hampered due to innate differences. We set out to identify loci influencing levels of serum cartilage oligomeric protein (sCOMP) and urinary C-telo...
July 23, 2014
Journal:
J Med Genet
Author:
Ramos YF, Metrustry S, Arden NK, Bay-Jensen AC, Beekman M, de Craen AJ, Cupples LA, Esko T, Evangelou E, Felson DT, Hart DJ, Ioannidis JP, Karsdal MA, Kloppenburg M, Lafeber F, Metspalu A, Panoutsopoulou K, Slagboom PE, Spector TD, van Spil EW, Uitterlinden AG, Zhu Y, Valdes AM, van Meurs JB, Meulenbelt I
Objective: To evaluate the role of three cartilage-derived biomarkers on osteoarthritis (OA): urinary C-terminal telopeptide (uCTX-II), serum cartilage oligomeric protein (sCOMP), and serum MMP degraded type II collagen (sC2M). Subjects and methods: Samples from 3582 individuals from the Rotterdam ...
May 22, 2014
Journal:
Osteoarthritis Cartilage
Author:
Meulenbelt I, Chassaing E, Arden NK, Bierma-Zeinstra SM, Hart D, Hofman A, Karsdal MA, Kloppenburg M, Kroon HM, Slagboom PE, Spector TD, Uitterlinden AG, van Meurs JB, Bay-Jensen AC, Valdes AM
Abstract Objective: Joint health is affected by local and systemic hormones. It is well accepted that systemic factors regulate the metabolism of joint tissues, and that substantial cross-talk between tissues actively contributes to homeostasis. In the current review, we try to define a subtype o...
May 20, 2013
Journal:
Menopause
Author:
Bay-Jensen AC, Chen-An P, Alexandersen P, Qvist P, Christiansen C, Meulenbelt I, Karsdal MA, Slagboom PE
Abstract Objectives: Individual metabolic characteristics and age-related changes may affect osteoarthritis (OA) risk as well as levels of potential OA biomarkers such as serum cartilage oligomeric protein (sCOMP) and urinary cross-linked C-telopeptide of type 2 collagen (uCTX2). We investigated ...
October 27, 2012
Journal:
Ann Rheum Dis
Author:
Bos SD, Beekman M, Maier AB, Karsdal MA, Kwok WY, Bay-Jensen AC, Kloppenburg M, Meulenbelt I, Slagboom PE
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