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This study investigated the association between body composition and risk of atrial fibrillation (AF) in postmenopausal women. In a retrospective analysis we assessed data from 5704 postmenopausal women (age 70.7 ± 6.5 yrs.) who in 1999-2001 participated in The Prospective Epidemiological Risk Facto...
January 17, 2020
Journal:
Sci Rep
Author:
Worm MS, Bager CL, Blair JPM, Secher NH, Riis BJ, Christiansen C, Nielsen HB
Chronic fibro-proliferative diseases are associated with nearly 45% of all deaths in the developed world. Matrix metalloproteinase (MMP) mediated remodeling of the extracellular matrix (ECM) plays an important role in disease development. Degradation of type I collagen is considered having a major r...
March 29, 2018
Journal:
Sci Rep
Author:
Bertelsen DM, Neergaard JS, Bager CL, Nielsen SH, Secher NH, Svendsen JH, Bihlet AR, Andersen JR, Karsdal MA, Christiansen C, Nielsen HB
Cerebral non-oxidative carbohydrate consumption may be driven by a β2-adrenergic mechanism. This study tested whether the 46G \u003e A (G16R) single nucleotide polymorphism of the β2-adrenergic receptor gene (ADRB2) influences the metabolic and cerebrovascular responses to administration of adrenali...
September 5, 2017
Journal:
Front Physiol
Author:
Rokamp KZ, Staalsø JM, Zaar M, Rasmussen P, Petersen LG, Nielsen RV, Secher NH, Olsen NV, Nielsen HB
To evaluate whether muscle vasodilatation plays a role for hypotension developed during central hypovolaemia, muscle oxygenation (Sm O2 ) was examined during (pre)syncope induced by head-up tilt (HUT). Skin blood flow (SkBF) and oxygenation (Sskin O2 ) were determined because evaluation of Sm O2 may...
September 1, 2017
Journal:
Acta Physiol (Oxf)
Author:
Lund A, Sørensen H, Jensen TW, Niemann MJ, Olesen ND, Nielsen HB, Olsen NV, Secher NH
In healthy humans, stroke volume (SV) and cardiac output (CO) do not increase with expansion of the central blood volume by head-down tilt or administration of fluid. Here, we exposed 85 patients to Trendelenburg\u0027s position about one hour after surgery while cardiovascular variables were determ...
BACKGROUND:The mechanisms underlying red blood cell (RBC)-mediated hypoxic vasodilation remain controversial, with separate roles for nitrite () and S-nitrosohemoglobin (SNO-Hb) widely contested given their ability to transduce nitric oxide bioactivity within the microcirculation. To establish their...
January 10, 2017
Journal:
Circulation
Author:
Bailey DM, Rasmussen P, Overgaard M, Evans KA, Bohm AM, Seifert T, Brassard P, Zaar M, Nielsen H, Raven PB, Secher NH
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