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BACKGROUND: The role of the extracellular matrix (ECM) structure and remodeling thereof in lung diseases is gaining importance. Pathology-related changes in ECM turnover may result in deleterious changes in lung architecture, leading to disease in the small airways. Here, degradation fragments of ty...
October 1, 2018
Journal:
chest
Author:
Kostikas K, Boersma W, Louis R, Aerts J, Wouters EFM, Rohde G, Prat C, Torres A, Welte T, Tamm M, Stolz D, Schumann D, Karsdal MA, Papakonstantinou E, Bülow Sand JM, Leeming DJ, Milenkovic B
BACKGROUND: Extracellular matrix (ECM) remodeling of the lung tissue releases protein fragments into the blood, where they may be detected as serologic surrogate markers of disease activity in COPD. Our goal was to assess the association of ECM turnover with severity and outcome of COPD. METHODS: I...
August 26, 2016
Journal:
Chest
Author:
Leeming DJ, Karsdal MA, Stolz D, Kristensen JH, Boersma W, Louis R, Milenkovic B, Kostikas K, Blasi F, Aerts J, Wouters EFM, Rohde G, Prat C, Torres A, Welte T, Papakonstantinou E, Tamm M, Bülow Sand JM, Rothe M
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