Publications
Find an abstract and a link to most of the publications produced by Nordic Bioscience
Find an abstract and a link to most of the publications produced by Nordic Bioscience
BACKGROUND: Change in forced expiratory volume in one second (FEV1) is important for defining severity of chronic obstructive pulmonary disease (COPD). Serological neoepitope markers of collagen turnover may predict rate of change in FEV1. METHODS: One thousand COPD subjects from the observational,...
December 4, 2017
Journal:
BMC Pulm Med.
Author:
Leeming DJ, Byrjalsen I, Bihlet AR, Lange P, Miller BE, Karsdal MA, Vestbo J, Thal-Singer R, Bülow Sand JM
BACKGROUND: There is a need to identify individuals with COPD at risk for disease progression and mortality. Lung tissue remodeling is associated with the release of extracellular matrix (ECM) fragments into the peripheral circulation. We hypothesized that ECM remodeling was associated with mortalit...
October 4, 2016
Journal:
Respir Res.
Author:
Leeming DJ, Byrjalsen I, Bihlet AR, Lange P, Miller BE, Karsdal MA, Vestbo J, Thal-Singer R, Bülow Sand JM
OBJECTIVES: hronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation that leads to excessive remodeling of the lung extracellular matrix (ECM), resulting in release of protein fragments (neo-epitopes) to the blood. Serological markers assessing this have previously been a...
September 7, 2016
Journal:
Clin Biochem
Author:
Lange P, Leeming DJ, Karsdal MA, Midjord AK, Martinez G, Bülow Sand JM
Despite massive investments in the development of novel treatments for heterogeneous diseases such as COPD, the resources spent have only benefited a fraction of the population treated. Personalized health care to guide selection of a suitable patient population already in the clinical development o...
July 1, 2015
Journal:
Chest
Author:
Bihlet AR, Karsdal MA, Bay-Jensen AC, Read S, Kristensen JH, Leeming DJ, Andersen JR, Lange P, Vestbo J, Bülow Sand JM
Background: Exacerbations of chronic obstructive pulmonary disease (COPD) contribute significantly to disease progression. However, the effect on tissue structure and turnover is not well described. There is an urgent clinical need for biomarkers of disease activity associated with disease progressi...
June 11, 2015
Journal:
Respir Res.
Author:
Knox AJ, Lange P, Sun S, Kristensen JH, Leeming DJ, Karsdal MA, Bolton CE, Johnson SR, Bülow Sand JM
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