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Extracellular matrix (ECM) remodeling is a hallmark of the pathology of gastrointestinal disorders. Collagen type VI (COL6) is produced by fibroblasts, and the COL6 α3-chain has shown to be elevated in patients with ulcerative colitis (UC), Crohn's disease (CD) and colorectal cancer (CRC). Measuring...
April 3, 2020
Journal:
Sci Rep
Author:
Nielsen SH, Mortensen JH, Willumsen N, Mogensen DJ, Di Sabatino A, Mazza G, Jørgensen LN, Pinzani M, Klinge LG, Kjeldsen J, Leeming DJ, Karsdal MA, Genovese F, Rasmussen DGK, Giuffrida P
Altered extracellular matrix (ECM) remodeling is an important part of the pathology of gastrointestinal (GI) disorders. In the intestine, type XVI collagen (col-16) plays a role in pathogenesis by affecting ECM architecture and induce cell invasion. Measuring col-16 in serum may therefore have bioma...
July 20, 2018
Journal:
Cancer Med
Author:
Jensen C, Nielsen SH, Mortensen JH, Kjeldsen J, Klinge LG, Harling H, Jørgensen LN, Karsdal MA, Willumsen N, Leeming DJ
BACKGROUND:Increased protease activity is a key pathological feature of inflammatory bowel disease (IBD). However, the differences in extracellular matrix remodelling (ECM) in Crohn\u0027s disease (CD) and ulcerative colitis (UC) are not well described. An increased understanding of the inflammatory...
October 13, 2017
Journal:
PLoS One
Author:
Bay-Jensen AC, Karsdal MA, Krag A, Kjeldsen J, Klinge LG, Hägglund P, Jensen MD, Manon-Jensen T, Mortensen JH
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