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Background Aberrant extracellular matrix (ECM) deposition and remodelling is important in the disease pathogenesis of pulmonary fibrosis (PF). We characterised neoepitope biomarkers released by ECM turnover in lung tissue from bleomycin-treated rats and patients with PF and analysed the effects of ...
August 4, 2022
Journal:
Respiratory Research
Author:
Hesse C, Beneke V, Konzok S, Diefenbach C, Bülow Sand JM, Rønnow S, Karsdal MA, Jonigk D, Sewald K, Braun A, Leeming DJ, Wollin L
Abstract Background: Asthma is a heterogeneous syndrome substantiating the urgent requirement for endotype-specific biomarkers. Dysbalance of fibrosis and fibrolysis in asthmatic lung tissue leads to reduced levels of the inflammation-protective collagen 4 (COL4A3). Objective: To delineate the degra...
July 29, 2021
Journal:
Eur Respir J
Author:
Weckmann M, Bahmer T, Rønnow S, Pech M, Vermeulen C, Faiz A, Karsdal MA, Lunding L, Oliver B, Wegmann M, Ulrich-Merzenich G, Juergens U, Duhn J, Laumonnier Y, Danov O, Sewald K, Zissler U, Jonker M, König I, Hansen G, Mutius E, Fuchs O, Dittrich AM, Schaub B, Happle C, Rabe K, de Berge M, Burgess J, Kopp M, Leeming DJ, Bülow Sand JM
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