Author

Journal

INTRODUCTION: The medical need in the haemophilic (HF) field to reduce bleeding incidents requires measurement of the annual bleeding rate (ABR) in haemophiliacs. Vascular rupture is associated with damage to the vascular endothelium causing exposure of the basement membrane. Endothelial cells and m...

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January 10, 2018

Journal:
PLoS One

Author:
Kjeld NG, Karsdal MA, Sun S, Manon-Jensen T, Hua BL

Altered extracellular matrix (ECM) turnover is a central pathological feature of many diseases. The ECM is a meshwork of molecules that provides structural support to cells throughout the body. It consists mainly of two membranes: the interstitial matrix, which is present between parenchymal cells i...

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Introduction: Progressive arthropathy caused by recurrent joint bleeds is a severe complication in haemophilia. Aim: We investigated whether biomarkers of cartilage and bone degradation, and inflammation were altered in haemophilia patients and whether these biomarkers could identify haemophilia pa...

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