Publications
Find an abstract and a link to most of the publications produced by Nordic Bioscience
Find an abstract and a link to most of the publications produced by Nordic Bioscience
PURPOSE OF REVIEW: This review focuses on the molecular taxonomy of osteoarthritis from the perspective of molecular biomarkers. We discuss how wet biochemical markers may be used to understand disease pathogenesis and progression and define molecular endotypes of osteoarthritis and how these corres...
January 31, 2019
Journal:
Curr Opin Rheumatol
Author:
mobasheri A, Van Spil WE, Budd E, Uzieliene I, Bernotiene E, Bay-Jensen AC, Larkin J, Levesque MC, Gualillo O, Henrotin Y
OBJECTIVE: Knee osteoarthritis (OA) is among the higher contributors to global disability. Despite its high prevalence, currently, there is no cure for this disease. Furthermore, the available diagnostic approaches have large precision errors and low sensitivity. Therefore, there is a need for new b...
September 9, 2017
Journal:
Osteoarthritis Cartilage
Author:
Bacardit J, Henrotin Y, Thudium CS, Bay-Jensen AC, Runhaar J, Lazzarini N, Bierma-Zeinstra SM
The extracellular matrix (ECM) of articular cartilage is comprised of complex networks of proteins and glycoproteins, all of which are expressed by its resident cell, the chondrocyte. Cartilage is a unique tissue given its complexity and ability to resist repeated load and deformation. The mechanism...
February 20, 2017
Journal:
Osteoarthritis Cartilage
Author:
Sanchez C, Bay-Jensen AC, Pap T, Dvir-Ginzberg M, Barrett-Jolley R, Mobasheri A, Henrotin Y, Quasnichka HL
Articular cartilage is a connective tissue consisting of a specialized extracellular matrix (ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are the main ECM proteins in cartilage. However, little attention has been paid to less abundant molecular components, es...
February 17, 2017
Journal:
Protein Cell
Author:
Luo Y, Sinkeviciute D, He Y, Karsdal MA, Henrotin Y, Mobasheri A, Önnerfjord P, Bay-Jensen AC
Osteoarthritis (OA) has traditionally been viewed as a non-inflammatory arthropathy and has not been considered a ‘serious disease’. However, this view has radically changed in recent years, due to the complexity and heterogeneity of the patient populations, spiralling socio-economical costs and lon...
Specific soluble biomarkers can be powerful tools for the diagnosis, prognosis and personalized management of osteoarthritis (OA). Biomarkers are potential indicators of the effect of a drug on cartilage metabolism and provide crucial information about the mechanisms of drug action. In this review, ...
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