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Extensive tissue remodeling mediated by matrix metalloproteases (MMPs) is an important part of cancer. The aim of this study was to investigate whether serum biomarkers reflecting MMP-mediated degradation of type I collagen (C1M), type IV collagen (C4M) and citrullinated vimentin (VICM) were predict...
February 11, 2017
Journal:
Oncotarget
Author:
Willumsen N, Bager CL, Kehlet SN, Dragsbaek K, Neergaard JS, Hansen HB, Bay-Jensen AC, Leeming DJ, Lipton A, Christiansen C, Karsdal MA
The world’s population is ageing. In Europe alone, the elderly population over age 65 will double from 88 to 153 million and the fastest growing segment of the population will be those over 80, tripling in number from 24 to 60 million in 2060. Low birth rates and increasing longevity are the key fac...
October 26, 2016
Journal:
Int J Epidemiol.
Author:
Neergaard JS, Dragsbæk K, Kehlet SN, Hansen HB, Hansen G, Byrjalsen I, Alexandersen P, Lindgren LM, Bihlet AR, Riis BJ, Andersen JR, Qvist P
The prognostic value of the metabolic syndrome (MetS) is believed to vary with age. With an elderly population expecting to triple by 2060, it is important to evaluate the validity of MetS in this age group. We examined the association of MetS risk factors with later risk of type 2 diabetes (T2DM) a...
September 15, 2016
Journal:
Medicine (Baltimore)
Author:
Dragsbæk K", Neergaard JS, Laursen JM, Hansen HB, Christiansen C, Beck-Nielsen H, Karsdal MA, Brix S, Henriksen K
BACKGROUND: An altered tumor microenvironment is one of the earliest signs of cancer and an important driver of the disease. We have seen previously that biomarkers reflecting tumor microenvironment modifications, such as matrix metalloproteinase (MMP)-degraded type 1 collagen (C1M), MMP-degraded ty...
July 13, 2016
Journal:
Cancer Epidemiol Biomarkers Prev.
Author:
Bager CL, Willumsen N, Kehlet SN, Hansen HB, Bay-Jensen AC, Leeming DJ, Dragsbæk K, Neergaard JS, Christiansen C, Høgdall E, Karsdal MA
Since the first evidence of a decline in dementia incidence was reported in 2011, the focus on modifiable risk factors has increased. The possibility of risk factor intervention as a prevention strategy has been widely discussed; however, further evidence in relation to risk factors is still needed....
March 1, 2016
Journal:
Medicine (Baltimore)
Author:
Neergaard JS, Dragsbæk K, Hansen HB, Henriksen K, Christiansen C, Karsdal MA
Acute myocardial infarction (AMI) is often underdiagnosed in women. It is therefore of interest to identify biomarkers that indicate increased risk of AMI and thereby help clinicians to have additional focus on the difficult AMI diagnosis. Type I Collagen, a component of the cardiac extracellular ma...
April 30, 2015
Journal:
EBioMedicine
Author:
Dragsbæk K, Neergaard JS, Hansen HB, Byrjalsen I, Alexandersen P, Kehlet SN, Bay-Jensen AC, Christiansen C, Karsdal MA
AIM:The aim of this project was to perform an empirical evaluation of the impact of on site source data verification (SDV) on the data quality in a clinical trial database to guide an informed decision on selection of the monitoring approach. METHODS:We used data from three randomized phase III tri...
October 19, 2014
Journal:
Br J Clin Pharmacol
Author:
Andersen JR, Byrjalsen I, Bihlet AR, Kalakou F, Hoeck HC, Hansen G, Hansen HB, Karsdal MA, Riis BJ
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